Selected publications, patents, and presentations related to TxGuard technology:


  1. Sinha, D., Nagy-Mehesz, A., Houde, A., Mayer, J.E., Vyavahare, N. (2022)
Regenerative vascular patch repair in Pediatric Cardiovascular Patients [Poster presentation].
    BMES Annual Meeting 2022, San Antonio, TX.
  2. Sinha, D., Nagy-Mehesz, A., Simionescu, D.T., Houde, A., Mayer, J.E., Vyavahare, N. (2021)
Decellularized Xenograft Valved Conduits for Pediatric Patients [Paper presentation].
    BMES Annual Meeting 2021, Orlando, FL.
  3. Sinha, D., Nagy-Mehesz, A., Simionescu, D.T., Houde, A., Mayer, J.E., Vyavahare, N. (2021)
    Decellularized Xenograft Leaflets for Pulmonary Valve Repair in Pediatric Patients [Poster presentation].
    BMES Annual Meeting 2021, Orlando, FL.


  1. Vyavahare, N., Tam, H. (2018).
    Advances in Heart Valve Biomechanics:
Bioprosthetic Heart Valves: From a Biomaterials Perspective.
    Springer, Cham.
  2. Deborde, C., Simionescu D.T., Liao, J., Sierad, L., Wright, C., Simionescu, A. (2016).
    Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering.
    Tissue Engineering Part A; 22(21-22):1241-1251.
  3. Pennel, T., Fercana, G., Bezuidenhout, D., Simionescu, A., Chuang, T., Zilla, P., Simionescu, D.T. (2014).
    The Performance of Cross-linked Acellular Arterial Scaffolds as Vascular Grafts; Pre-clinical Testing in Direct and Isolation Loop Circulatory Models.
    Biomaterials. 35(24); 6311-22.
  4. Tripi, D.R., Vyavahare, N.R. (2014).
    Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves.
    Journal of biomaterials applications, 28(5), 757-766. 10.1177/0885328213479047
  5. Sinha, A., Nosoudi, N., & Vyavahare, N. (2014).
    Elasto-regenerative properties of polyphenols.
    Biochemical and biophysical research communications, 444(2), 205-211.
  6. Chow, P., Simionescu, D.T., Warner, H., Wang, B., Patnaik, S.S., Liao, J., Simionescu, A. (2013).
    Mitigation of Diabetes-Related Complications in Implanted Collagen and Elastin Scaffolds Using Matrix-Binding Polyphenol.
Biomaterials. 34(3): 685-695.
  7. Munnelly, A. E., Cochrane, L., Leong, J., Vyavahare, N. R. (2012).
    Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves.
    Biomaterials, 33(1), 1-8.
  8. Tedder, M.E., Liao, J., Weed, B., Stabler, C., Zhang, H., Simionescu, A., Simionescu, D.T. (2009).
    Stabilized collagen scaffolds for heart valve tissue engineering.
    Tissue Engineering Part A. 15(6): 1257-1268.
  9. Chuang, T.H., Stabler, C., Simionescu, A., Simionescu, D.T. (2009).
    Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.
    Tissue Engineering Part A. 15(10): 1257-1268.
  10. Isenburg, J.C., Simionescu, D.T., Starcher, B.C., Vyavahare, N.R. (2007).
    Elastin stabilization for treatment of abdominal aortic aneurysms.
    Circulation, 115(13), 1729-1737.
  11. Simionescu, D.T., Lu, Q., Song, Y., Lee, J., Rosenbalm, T.N., Kelley, C., Vyavahare, N.R. (2006).
    Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds.
    Biomaterials, 27(5), 702-713.
  12. Isenburg, J.C., Karamchandani, N.V., Simionescu, D.T., Vyavahare, N.R. (2006).
    Structural requirements for stabilization of vascular elastin by polyphenolic tannins.
    Biomaterials, 27(19), 3645-3651. 10.1016/j.biomaterials.2006.02.016
  13. Isenburg, J.C., Simionescu, D.T., Vyavahare, N.R. (2005).
    Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall.
    Biomaterials, 26(11), 1237-1245.
  14. Isenburg, J.C., Simionescu, D.T., Vyavahare, N.R. (2004).
    Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid.
    Biomaterials, 25(16), 3293-3302. 10.1016/j.biomaterials.2003.10.001


  1. Vyavahare, N., Simionescu, D.T., Nagy-Mehesz, A., Houde, A. (2022).
Systems and Methods for Processing Tissue.
    (U.S. Patent Application No. US17/446,953). Washington, D.C.: US Patent and Trademark Office.
  2. Vyavahare, N.R., Isenberg, J.C., Simionescu, D.T. (2010).
    Elastin Stabilization of Connective Tissue.
    (U.S. Patent No. 7,713,543). Washington, D.C.: U.S Patent and Trademark Office.
  3. Simionescu, D.T., Vyavahare, N. (2007).
    Tissue material process for forming bioprosthesis.
    (U.S. Patent No. 7,189,259). Washington, D.C.: U.S. Patent and Trademark Office.