Breakthrough innovations. A world of applications.

Decellularized tissue-based scaffolds are used in many tissue repair applications. Annoviant’s unique TxGuard™ technology allows tissue to be stabilized by physical crosslinking with an antioxidant agent that allows host cell repopulation of the scaffold when implanted without causing rapid degradation of scaffold. This allows infiltrated cells to develop their own matrix as the old matrix slowly degrades.

  • Any decellularized tissue (allograft, xenograft) can be physically stabilized so it retains its strength, pliability, and suture strength. It can be stored ready to use for two years.
  • Immunogenic cellular materials are removed to make the scaffold less immunogenic.
  • Antioxidant present in the tissue prevents oxidative damage to the tissue during remodeling.
  • No in vitro bioreactor/stem cell manipulation required thus less stringent FDA requirement.
  • TxGuard technology makes scaffold resistant to calcification and thrombosis.
  • TxGuard promote remodeling of scaffold while reducing inflammatory response.
  • Possibility of remodeling/growth especially for juvenile patients

TxGuard™ tissue stabilization technology provides benefits across a wide range of soft tissue surgical applications where regeneration of tissue is desirable:

Bridging of fascial defects – Self healing patch for skin repair
Cardiovascular Devices – Nonthrombogenic and calcification resistant
Duodenal injury patch – Decellularized small intestinal submucosa
Passive biological membrane – Surgical adhesion prevention during surgery, dura mater, peritoneum
Bladder tissue – Elastic tissue graft
Hernia repair patch, inguinal herniorrhaphy – Regenerative pericardium patch
Wound healing – Infection-resistant elastic patch
Venous valve graft – Nonthrombogenic graft


Thrombo Resistant

Calcification Resistant