Selected presentations, publications, and patents related to TxGuard technology:

Presentations

  1. Sinha, D., Nagy-Mehesz, A., Houde, A., Mayer, J.E., Vyavahare, N. (2022)
Regenerative vascular patch repair in Pediatric Cardiovascular Patients [Poster presentation].
    BMES Annual Meeting 2022, San Antonio, TX.
  2. Sinha, D., Nagy-Mehesz, A., Simionescu, D.T., Houde, A., Mayer, J.E., Vyavahare, N. (2021)
Decellularized Xenograft Valved Conduits for Pediatric Patients [Paper presentation].
    BMES Annual Meeting 2021, Orlando, FL.
  3. Sinha, D., Nagy-Mehesz, A., Simionescu, D.T., Houde, A., Mayer, J.E., Vyavahare, N. (2021)
    Decellularized Xenograft Leaflets for Pulmonary Valve Repair in Pediatric Patients [Poster presentation].
    BMES Annual Meeting 2021, Orlando, FL.

Publications

  1. Vyavahare, N., Tam, H. (2018).
    Advances in Heart Valve Biomechanics:
Bioprosthetic Heart Valves: From a Biomaterials Perspective.
    Springer, Cham.
    https://doi.org/10.1007/978-3-030-01993-8_14
  2. Deborde, C., Simionescu D.T., Liao, J., Sierad, L., Wright, C., Simionescu, A. (2016).
    Stabilized collagen and elastin-based scaffolds for mitral valve tissue engineering.
    Tissue Engineering Part A; 22(21-22):1241-1251.
    https://doi.org/10.1089/ten.tea.2016.0032
  3. Pennel, T., Fercana, G., Bezuidenhout, D., Simionescu, A., Chuang, T., Zilla, P., Simionescu, D.T. (2014).
    The Performance of Cross-linked Acellular Arterial Scaffolds as Vascular Grafts; Pre-clinical Testing in Direct and Isolation Loop Circulatory Models.
    Biomaterials. 35(24); 6311-22.
    https://doi.org/10.1016/j.biomaterials.2014.04.062
  4. Tripi, D.R., Vyavahare, N.R. (2014).
    Neomycin and pentagalloyl glucose enhanced cross-linking for elastin and glycosaminoglycans preservation in bioprosthetic heart valves.
    Journal of biomaterials applications, 28(5), 757-766.
    https://doi.org/ 10.1177/0885328213479047
  5. Sinha, A., Nosoudi, N., & Vyavahare, N. (2014).
    Elasto-regenerative properties of polyphenols.
    Biochemical and biophysical research communications, 444(2), 205-211.
    https://doi.org/10.1016/j.bbrc.2014.01.027
  6. Chow, P., Simionescu, D.T., Warner, H., Wang, B., Patnaik, S.S., Liao, J., Simionescu, A. (2013).
    Mitigation of Diabetes-Related Complications in Implanted Collagen and Elastin Scaffolds Using Matrix-Binding Polyphenol.
Biomaterials. 34(3): 685-695.
    https://doi.org/10.1016/j.biomaterials.2012.09.081
  7. Munnelly, A. E., Cochrane, L., Leong, J., Vyavahare, N. R. (2012).
    Porcine vena cava as an alternative to bovine pericardium in bioprosthetic percutaneous heart valves.
    Biomaterials, 33(1), 1-8.
    https://doi.org/10.1016/j.biomaterials.2011.09.027
  8. Tedder, M.E., Liao, J., Weed, B., Stabler, C., Zhang, H., Simionescu, A., Simionescu, D.T. (2009).
    Stabilized collagen scaffolds for heart valve tissue engineering.
    Tissue Engineering Part A. 15(6): 1257-1268.
    https://doi.org/10.1089/ten.tea.2008.0263
  9. Chuang, T.H., Stabler, C., Simionescu, A., Simionescu, D.T. (2009).
    Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.
    Tissue Engineering Part A. 15(10): 1257-1268.
    https://doi.org/10.1089/ten.TEA.2008.0394
  10. Isenburg, J.C., Simionescu, D.T., Starcher, B.C., Vyavahare, N.R. (2007).
    Elastin stabilization for treatment of abdominal aortic aneurysms.
    Circulation, 115(13), 1729-1737.
    https://doi.org/10.1161/CIRCULATIONAHA.106.672873
  11. Simionescu, D.T., Lu, Q., Song, Y., Lee, J., Rosenbalm, T.N., Kelley, C., Vyavahare, N.R. (2006).
    Biocompatibility and remodeling potential of pure arterial elastin and collagen scaffolds.
    Biomaterials, 27(5), 702-713.
    https://doi.org/10.1016/j.biomaterials.2005.06.013
  12. Isenburg, J.C., Karamchandani, N.V., Simionescu, D.T., Vyavahare, N.R. (2006).
    Structural requirements for stabilization of vascular elastin by polyphenolic tannins.
    Biomaterials, 27(19), 3645-3651.
    https://doi.org/ 10.1016/j.biomaterials.2006.02.016
  13. Isenburg, J.C., Simionescu, D.T., Vyavahare, N.R. (2005).
    Tannic acid treatment enhances biostability and reduces calcification of glutaraldehyde fixed aortic wall.
    Biomaterials, 26(11), 1237-1245.
    https://doi.org/10.1016/j.biomaterials.2004.04.034
  14. Isenburg, J.C., Simionescu, D.T., Vyavahare, N.R. (2004).
    Elastin stabilization in cardiovascular implants: improved resistance to enzymatic degradation by treatment with tannic acid.
    Biomaterials, 25(16), 3293-3302.
    https://doi.org/ 10.1016/j.biomaterials.2003.10.001

Patents

  1. US Patent, 9,283,241B2 (2016), “Treatment to render implants resistant to diabetes”
  2. US Patent, 9,795,573B2 (2017), “Multi-step connective tissue stabilization method and stabilized tissue formed thereby”
  3. Patent Applications, US 2022/0073869A1 (2021) & WO2022051777A1 (2022), “Systems and methods for processing tissue”
  4. Patent Applications US 63/519,585 (2023) & PCT/US24/42516 (2024) “Decellularized biological scaffolds with physical stabilization for in situ tissue engineering applications”